Article

Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential

2025-04-14

Abstract excerpt

Adult stem cells maintain tissue homeostasis, yet are themselves vulnerable to loss. One common mechanism to replace lost stem cells is dedifferentiation, in which progeny revert to stem cell identity. It is a paradox how stem cells and progeny retain the same stem cell potential while exhibiting distinct current identities of self-renewal, differentiation, and dedifferentiation. Here, we show that the Drosophila...

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Literature Corpus work: 2967343d-8b8a-5d82-8046-628e0d9321f5
DOI: 10.1101/2025.04.10.648217

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