Article

Senolytic treatment depletes microglia and decreases severity of experimental autoimmune encephalomyelitis

2024-02-06

Abstract excerpt

The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent cells improves outcomes in a variety of contexts particularly related to aging, cognition, and neurodegeneration. Here, the effect of a bioinformatically-rationalized senolytic was tested in the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis (MS). Single-cell...

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Literature Corpus work: e57db5ef-bd04-523b-a833-7d7ae36c2a0b
DOI: 10.1101/2024.02.05.579017

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