Article

A promoter interaction map for cardiovascular disease genetics

2018-06-08

Abstract excerpt

Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs), however most loci are located in gene-distal non-coding regions and their target genes are not known. Here, we generated high-resolution promoter capture Hi-C (PCHi-C) maps in human induced pluripotent stem cells (iPSCs) and iPSC-derived cardiomyocytes (CMs) to provide a resource for identifying and prioritizing the functional...

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Literature Corpus work: 61419c3b-2473-5f37-8700-2b48a15d9f7f
DOI: 10.1101/340869

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