Article
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C.
Nature genetics - 1 Jun 2015
Mifsud Borbala, Tavares-Cadete Filipe, Young Alice N, Sugar Robert, Schoenfelder Stefan, Ferreira Lauren, Wingett Steven W, Andrews Simon, Grey William, Ewels Philip A, Herman Bram, Happe Scott, Higgs Andy, LeProust Emily, Follows George A, Fraser Peter, Luscombe Nicholas M, Osborne Cameron S
Abstract excerpt
Transcriptional control in large genomes often requires looping interactions between distal DNA elements, such as enhancers and target promoters. Current chromosome conformation capture techniques do not offer sufficiently high resolution to interrogate these regulatory interactions on a genomic scale. Here we use Capture Hi-C (CHi-C), an adapted genome conformation assay, to examine the long-range interactions...
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