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Article

A promoter interaction map for cardiovascular disease genetics.

eLife - 10 Jul 2018

Montefiori Lindsey E, Sobreira Debora R, Sakabe Noboru J, Aneas Ivy, Joslin Amelia C, Hansen Grace T, Bozek Grazyna, Moskowitz Ivan P, McNally Elizabeth M, Nóbrega Marcelo A

Abstract excerpt

Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs); however, most loci are located in gene-distal non-coding regions and their target genes are not known. Here, we generated high-resolution promoter capture Hi-C (PCHi-C) maps in human induced pluripotent stem cells (iPSCs) and iPSC-derived cardiomyocytes (CMs) to provide a resource for identifying and prioritizing the...

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Share to Cardiovascular Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome, Human

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Share to Myocytes, Cardiac

Share to Regulatory Elements, Transcriptional

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Identifiers

PMID: 29988018
DOI: 10.7554/eLife.35788
PMCID: PMC6053306

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