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Article

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data.

Nature communications - 28 Apr 2020

Wu Yang, Qi Ting, Wang Huanwei, Zhang Futao, Zheng Zhili, Phillips-Cremins Jennifer E, Deary Ian J, McRae Allan F, Wray Naomi R, Zeng Jian, Yang Jian

Abstract excerpt

Promoter-anchored chromatin interactions (PAIs) play a pivotal role in transcriptional regulation. Current high-throughput technologies for detecting PAIs, such as promoter capture Hi-C, are not scalable to large cohorts. Here, we present an analytical approach that uses summary-level data from cohort-based DNA methylation (DNAm) quantitative trait locus (mQTL) studies to predict PAIs. Using mQTL data from human...

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Identifiers

PMID: 32345984
DOI: 10.1038/s41467-020-15587-0
PMCID: PMC7188843

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