Article

Human atlas of cardiac promoters and enhancers reveals important role of regulatory elements in heritable diseases

2020-07-09

Abstract excerpt

<title>Abstract</title> <p>Genome regulatory elements play a critical role during cardiac development and maintenance of normal physiological homeostasis, and genome-wide association studies identified a large number of SNPs associated with cardiovascular diseases localized in intergenic zones. We used cap analysis of gene expression (CAGE) to identify transcription start sites (TSS) with one nucleotide resolutio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8813388a-6b06-5e2e-b78d-4251ef8189aa
DOI: 10.21203/rs.3.rs-37530/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human atlas of cardiac promoters and enhancers reveals important role of regulatory elements in heritable diseasesDOI 10.21203/rs.3.rs-37530/v1Read

Human library of cardiac promoters and enhancersSemantic proximity Read

The atlas of human cardiac promoters and enhancers reveals an important role for regulatory elements in heart failureSemantic proximity Read

Cardiac Cell Type-Specific Gene Regulatory Programs and Disease Risk AssociationSemantic proximity Read

Enhancer and promoter usage in the normal and failed human heartSemantic proximity Read

Altered Enhancer and Promoter Usage Leads to Differential Gene Expression in the Normal and Failed Human HeartSemantic proximity Read

Mammalian epigenomic conservation of promoters and enhancers in the heart associates with trait-associated variation and impacts cardiomyocyte phenotypesSemantic proximity Read

Linking Chamber-Specific Spatial Chromatin Interactions to Disease Variants and Gene Programs in Human CardiomyocytesSemantic proximity Read

Linking Chamber-Specific Spatial Chromatin Interactions to Disease Variants and Gene Programs in Human CardiomyocytesSemantic proximity Read

Sex modulates the human genome regulatory network during heart failure and aging.Semantic proximity Read

Genome-wide analysis of functional and evolutionary features of tele-enhancers.Semantic proximity Read

Genome-wide compendium and functional assessment of in vivo heart enhancers.Semantic proximity Read

Computational analysis of congenital heart disease associated SNPs: Unveiling their impact on the gene regulatory systemSemantic proximity Read