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A systems biology-based identification and <i>in vivo</i> functional screening of Alzheimer’s disease risk genes reveals modulators of memory function

2022-08-22

Abstract excerpt

<h4>Summary</h4> Genome-wide association studies (GWAS) have uncovered over 40 genomic loci associated with risk for late-onset Alzheimer’s Disease (LOAD), but identification of the underlying causal genes remains challenging. While the role of glial biology in the mediation of LOAD genetic risk has been increasingly recognized, recent studies of induced pluripotent stem cell (iPSC)-derived neurons from LOAD pati...

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Literature Corpus work
60c2793a-4297-5dfe-ad50-fffa8ff69767
DOI
10.1101/2022.08.19.504537
Open publication

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A systems biology-based identification and <i>in vivo</i> functional screening of Alzheimer’s disease risk genes reveals modulators of memory functionDOI 10.1101/2022.08.19.504537
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