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Article

A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveal modulators of memory function.

Neuron - 3 Jul 2024

Hudgins Adam D, Zhou Shiyi, Arey Rachel N, Rosenfeld Michael G, Murphy Coleen T, Suh Yousin

Abstract excerpt

Genome-wide association studies (GWASs) have uncovered over 75 genomic loci associated with risk for late-onset Alzheimer's disease (LOAD), but identification of the underlying causal genes remains challenging. Studies of induced pluripotent stem cell (iPSC)-derived neurons from LOAD patients have demonstrated the existence of neuronal cell-intrinsic functional defects. Here, we searched for genetic contributions...

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Identifiers

PMID: 38692279
DOI: 10.1016/j.neuron.2024.04.009
PMCID: PMC11223975

Genes

ACP2
ATP6V1G2
BIN1
CALM3
NGEF

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