Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.

doi:10.1016/j.jalz.2017.01.016

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Article

Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2017

Mukherjee Shubhabrata, Russell Joshua C, Carr Daniel T, Burgess Jeremy D, Allen Mariet, Serie Daniel J, Boehme Kevin L, Kauwe John S K, Naj Adam C, Fardo David W, Dickson Dennis W, Montine Thomas J, Ertekin-Taner Nilufer, Kaeberlein Matt R, Crane Paul K

Abstract excerpt

INTRODUCTION: We sought to determine whether a systems biology approach may identify novel late-onset Alzheimer's disease (LOAD) loci. METHODS: We performed gene-wide association analyses and integrated results with human protein-protein interaction data using network analyses. We performed functional validation on novel genes using a transgenic Caenorhabditis elegans Aβ proteotoxicity model and evaluated novel...

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PMID: 28242297
DOI: 10.1016/j.jalz.2017.01.016
PMCID: PMC5568992

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NDUFS3
APP
EGR1
UBC

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