Article

An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration

2024-03-17

Abstract excerpt

Despite years of intense investigation, the mechanisms underlying neuronal death in Alzheimer’s disease, the most common neurodegenerative disorder, remain incompletely understood. To define relevant pathways, we integrated the results of an unbiased, genome-scale forward genetic screen for age-associated neurodegeneration in Drosophila with human and Drosophila Alzheimer’s disease-associated multi-omics. We mea...

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Literature Corpus work: b934be24-3371-5843-95bc-3dbfb419affd
DOI: 10.1101/2024.03.17.585262

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