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Functional Analysis of Late-Onset Alzheimer’s Disease Risk Genes in <i>Caenorhabditis elegans</i> Identifies Regulators of Neuronal Aging

2026-03-30

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<h4>ABSTRACT</h4> <h4>Background</h4> Genome-wide studies in late-onset Alzheimer’s disease (LOAD) have uncovered many risk loci, yet identifying the causal genes and clarifying how these genetic signals connect to molecular and cellular mechanisms relevant to AD pathogenesis in vivo remains challenging. <h4>Methods</h4> Using Caenorhabditis elegans as a model to identify LOAD-associated genes that drive neu...

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Literature Corpus work: cf7924b9-e4e3-58b3-b3d1-8f76d8a864ee
DOI: 10.64898/2026.03.26.714531

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