Article

Revealing the nervous system requirements of Alzheimer’s disease risk genes in <i>Drosophila</i>

2025-07-30

Abstract excerpt

Most Alzheimer’s disease (AD) susceptibility genes have poorly understood roles in the central nervous system (CNS). To address this gap, we systematically characterized 100 conserved candidate AD risk genes using a cross-species strategy in the fruit fly, Drosophila melanogaster . Genes were prioritized based primarily on human functional genomic evidence. We generated custom, loss-of-function alleles for each o...

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Literature Corpus work: f2c31ef3-e272-518f-b21a-284685f5f343
DOI: 10.1101/2025.07.24.666383

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