Article

Genetic risk implicating endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer’s disease

2025-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Late-onset Alzheimer’s disease (LOAD) has a complex genomic architecture. LOAD risk variants suggest multiple pathways, including the endolysosomal network (ELN), contribute to the pathobiology of Alzheimer’s disease (AD). Whether genetic risk in specific pathways correlates with corresponding biological dysfunction remains largely unknown. We developed an endolysosomal pathway-specific polygeni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7662a41-cdb1-55a6-926f-a3bbb68b1240
DOI: 10.1101/2025.03.16.643481

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic risk implicating endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer’s diseaseDOI 10.1101/2025.03.16.643481Read

Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences.Semantic proximity Read

The role of Alzheimer's disease risk genes in endolysosomal pathways.Semantic proximity Read

Genetic variation within endolysosomal system is associated with late-onset Alzheimer's disease.Semantic proximity Read

Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal TransportSemantic proximity Read

A systems biology-based identification and <i>in vivo</i> functional screening of Alzheimer’s disease risk genes reveals modulators of memory functionSemantic proximity Read

Factorization of Alzheimer’s disease genetic risk influences allow patient stratification, predicting disease onset, cognitive decline, and cell-type specific responsesSemantic proximity Read

Defining the Genetic Architecture of Alzheimer's Disease: Where Next.Semantic proximity Read

Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriersSemantic proximity Read

Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease.Semantic proximity Read

Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkersSemantic proximity Read

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.Semantic proximity Read

Neuroimaging-derived brain endophenotypes link molecular mechanisms to Alzheimer’s disease and agingSemantic proximity Read