Article

Computational Design of a De Novo Binder for Claudin-6 (CLDN6)

2025-11-05

Abstract excerpt

Claudin-6 (CLDN6) is a tight-junction membrane protein normally expressed in embryonic tissues but abnormally activated in several cancers, where it contributes to tumor growth and metastasis. Its restricted oncofetal expression makes CLDN6 an attractive target for selective cancer therapies, yet designing molecules that bind its small, flexible extracellular loops has proven challenging. Here, we report the first...

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Literature Corpus work: 607de8b8-23be-5d7b-b438-701d50a8cc02
DOI: 10.20944/preprints202511.0284.v1

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