Article

A Computational Foundation Toward Targeting the ELMO1/DOCK2 Complex

2026-07-28

Abstract excerpt

Engulfment and Cell Motility protein 1 (ELMO1) regulates cell migration, phagocytosis, and cytoskeletal remodeling, positioning it as a compelling therapeutic target across kidney diseases, oncology, enteric infections and inflammation. Despite this potential, no approved therapeutics or clinically validated small-molecule modulators of ELMO1 currently exist. ELMO1 functions by forming a complex with DOCK180 (or D...

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Literature Corpus work: b1c4c506-2059-5524-8e01-06e6b45ba486
DOI: 10.64898/2026.07.27.740996

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