Article

The Impact of Pathogenic and Artificial Mutations on Claudin-5 Selectivity from Molecular Dynamics Simulations

2023-02-01

Abstract excerpt

Tight junctions (TJs) are multi-protein complexes at the interface between adjacent endothelial or epithelial cells. In the blood-brain barrier (BBB), they are responsible for sealing the paracellular spaces and their backbone is formed by Claudin-5 (Cldn5) proteins. Despite the important role in preserving brain homeostasis, little is known on how Cldn5 oligomers assemble. Different structural models have been su...

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Literature Corpus work: a3cc0b30-6e11-5a05-9595-8d5f047c7f54
DOI: 10.1101/2023.01.30.526089

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