Article

<i>De novo</i> and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics

2025-09-07

Abstract excerpt

Growth differentiation factor 15 (GDF15), a stress-responsive cytokine of the TGF-β superfamily, is elevated in cancer cachexia, chemotherapy-induced nausea, and hyperemesis gravidarum, making it both a biomarker and a therapeutic target. Here, we developed high-affinity GDF15 binders using an AI-driven protein design framework. To achieve this, we systematically explored three complementary scaffold-generation st...

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Literature Corpus work: 9e3d0a9d-971f-501c-826a-3478d6405c68
DOI: 10.1101/2025.09.03.673894

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