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Article

Locuaz: an in silico platform for protein binders optimization.

Bioinformatics (Oxford, England) - 2 Aug 2024

Barletta German P, Tandiana Rika, Soler Miguel, Fortuna Sara, Rocchia Walter

Abstract excerpt

MOTIVATION: Engineering high-affinity binders targeting specific antigenic determinants remains a challenging and often daunting task, requiring extensive experimental screening. Computational methods have the potential to accelerate this process, reducing costs and time, but only if they demonstrate broad applicability and efficiency in exploring mutations, evaluating affinity, and pruning unproductive mutation...

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Identifiers

PMID: 39107888
DOI: 10.1093/bioinformatics/btae492
PMCID: PMC11324344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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