Article
TET genes: new players in DNA demethylation and important determinants for stemness.
Experimental hematology - 1 Mar 2011
Mohr Fabian, Döhner Konstanze, Buske Christian, Rawat Vijay P S
Abstract excerpt
Stem cells are defined as cells that have the ability to perpetuate themselves through self-renewal and to generate functional mature cells by differentiation. During each stage, coordinated gene expression is crucial to maintain the balance between self-renewal and differentiation. Disturbance of this accurately balanced system can lead to a variety of malignant disorders. In mammals, DNA cytosine-5 methylation...
Topics
- Animals
- DNA Methylation
- DNA-Binding Proteins
- Dioxygenases
- Embryonic Stem Cells
- Epigenesis, Genetic
- Hematologic Neoplasms
- Humans
- Mutation
- Proto-Oncogene Proteins