Article
TET1 is a tumor suppressor of hematopoietic malignancy.
Nature immunology - 1 Jun 2015
Cimmino Luisa, Dawlaty Meelad M, Ndiaye-Lobry Delphine, Yap Yoon Sing, Bakogianni Sofia, Yu Yiting, Bhattacharyya Sanchari, Shaknovich Rita, Geng Huimin, Lobry Camille, Mullenders Jasper, King Bryan, Trimarchi Thomas, Aranda-Orgilles Beatriz, Liu Cynthia, Shen Steven, Verma Amit K, Jaenisch Rudolf, Aifantis Iannis
Abstract excerpt
The methylcytosine dioxygenase TET1 ('ten-eleven translocation 1') is an important regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished expression of TET proteins and loss of 5hmC in many tumors suggests a critical role for the maintenance of this epigenetic modification. Here we found that deletion of Tet1 promoted the development of B cell lymphoma in mice. TET1 was required for...
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