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Article

Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch

1 Feb 2023

Abstract excerpt

The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of DNA demethylation. To define the in vivo consequences of complete TET deficiency, we inducibly deleted all three Tet genes in the mouse genome. Tet1/2/3-inducible TKO ( iTKO ) mice succumbed to acute myeloid leukemia (AML) by 4 to 5 wk....

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PMID: 37406303
DOI: 10.1073/pnas.2214824120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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