Article

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

2017-04-07

Abstract excerpt

Mammalian TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine and higher oxidized derivatives. TETs are targets of the enzyme OGT, which post-translationally modifies intracellular proteins in response to cellular nutrient status. The biological implications of the OGT-TET interaction have not been thoroughly explored. Here, we show for the first time that modification of TET1 by OGT enhances its activ...

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Literature Corpus work: 36a942b8-fb5c-5426-867b-b093f21d39d9
DOI: 10.1101/125419

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