Article
Mutation in THO2, a component of THO/TREX complex, causes transcriptional gene silencing and genome-wide DNA methylation changes.
The Plant journal : for cell and molecular biology - 1 Jan 2026
La Yumei, Hu Tiange, Lu Chong, Yang Rongdi, Zhou Yi, Wang Qianqian, Liu Yan, Sang Liran, Sun Yifei, Chen Fei, Munyuru Joseph Ndirangu, Zhai Zhaoyu, Emam Mohamed A, Mohamed Osman M A, Zhou Shaoxia, La Honggui
Abstract excerpt
DNA methylation plays important roles in silencing of transgenes, endogenous genes, and transposable elements (TEs). To identify genes involved in antagonizing transcriptional or DNA hypermethylation-induced gene silencing, a genetic screening was conducted and thus a tho2-8 mutant was recovered. THO2 is a major component of the THO/TREX (Transcription-Export) complex, which plays essential roles in mRNA export....
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