Article

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

2018-01-25

Abstract excerpt

TET enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine and higher oxidized derivatives. TETs stably associate with and are post-translationally modified by the nutrient-sensing enzyme OGT, suggesting a connection between metabolism and the epigenome. Here, we show for the first time that modification by OGT enhances TET1 activity in vitro. We identify a domain of TET1 responsible for binding to OGT and r...

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Literature Corpus work: 36e06b61-5c3f-5c7a-9811-c3e4fb20fcd2
DOI: 10.1101/253872

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