Article

Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

2021-07-29

Abstract excerpt

Small cell lung cancer (SCLC) is a recalcitrant cancer featured with high metastasis. However, the exact cell type contributing to metastasis remains elusive. Using Rb1 L/L /Trp53 L/L mouse model, we identify the NCAM hi CD44 lo/− subpopulation as SCLC metastasizing cell (SMC), which is progressively transitioned from non-metastasizing NCAM lo CD44 hi cell (Non-SMC). Integrative chromatin accessibility and ge...

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Literature Corpus work: 60599e99-5017-55ff-bd77-3da94d8bc5dc
DOI: 10.1101/2021.07.28.454244

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