Article

FOXM1 targeting alters AURKB activity and reshapes antitumor immunity to curb the progression of small cell lung cancer

2025-07-01

Abstract excerpt

<title>Abstract</title> <p> Background Small cell lung cancer (SCLC) is a lethal lung malignancy and patients are often diagnosed with distant metastasis. Nearly all patients suffer from disease relapsing with inherent chemoresistance. Lack of targeted SCLC therapies further worsens disease outcomes, making it highly desirable to identify novel and effective therapeutic targets. Methods To search for potential...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2c45220-0fd2-5899-958e-823d40fa7562
DOI: 10.21203/rs.3.rs-6960266/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FOXM1 targeting alters AURKB activity and reshapes antitumor immunity to curb the progression of small cell lung cancerDOI 10.21203/rs.3.rs-6960266/v1Read

Small cell lung cancer: Novel treatments beyond immunotherapySemantic proximity Read

Small cell lung cancer: emerging subtypes, signaling pathways, and therapeutic vulnerabilitiesSemantic proximity Read

FOXM1 is required for small cell lung cancer tumorigenesis and associated with poor clinical prognosisSemantic proximity Read

Transcriptomic analysis of transformed small-cell lung cancer from EGFR-mutated lung adenocarcinoma reveals distinct subgroups and precision therapy opportunitiesSemantic proximity Read

Molecular classification of small cell lung cancer subtypes: Characteristics, prognostic factors, and clinical translation.Semantic proximity Read

Molecular Subtypes and Targeted Therapeutic Strategies in Small Cell Lung Cancer: Advances, Challenges, and Future PerspectivesSemantic proximity Read

Small-cell lung cancer.Semantic proximity Read

MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axisSemantic proximity Read

SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signaturesSemantic proximity Read

Cisplatin resistance-related transcriptome and methylome integration identifies PCDHB4 as a novel prognostic biomarker in small cell lung cancerSemantic proximity Read

Molecular Subtypes and Tumor Microenvironment Characteristics of Small-Cell Lung Cancer Associated with Platinum-ResistanceSemantic proximity Read

SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic SignaturesSemantic proximity Read