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Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

31 Dec 2021

Abstract excerpt

Abstract Small-cell lung cancer (SCLC) is a recalcitrant cancer characterized by high metastasis. However, the exact cell type contributing to metastasis remains elusive. Using a Rb1L/L/Trp53L/L mouse model, we identify the NCAMhiCD44lo/– subpopulation as the SCLC metastasizing cell (SMC), which is progressively transitioned from the non-metastasizing NCAMloCD44hi cell (non-SMC). Integrative chromatin...

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PMID: 35967587
DOI: 10.1093/nsr/nwab232

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