Deciphering the role of immunoglobulin secreting malignant lineages in the invasive frontiers of small cell lung cancer by scRNA-seq and spatial transcriptomics analysis

Abstract excerpt

Lung cancer remains the leading cause of cancer-related death worldwide 1 . Small cell lung cancer (SCLC) comprises ~14% of lung cancer and causes 200,000 deaths globally 2 . SCLC is characterized by the development of treatment resistance and the early-onset of widespread metastasis. Despite numerous clinical trials conducted over the past decades, the prognosis for SCLC patients has not significantly improved,...

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