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Article

Involvement of epithelial-mesenchymal transition genes in small cell lung cancer phenotypic plasticity

2022-09-11

Abstract excerpt

Small cell lung cancer (SCLC) is an aggressive cancer recalcitrant to treatment, arising predominantly from epithelial pulmonary neuroendocrine (NE) cells. Intra-tumor heterogeneity plays critical roles in SCLC disease progression, metastasis and treatment resistance. At least five transcriptional SCLC NE and non-NE cell subtypes were recently defined by gene expression signatures. Transition from NE to non-NE cel...

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Literature Corpus work
3e2dd723-8057-5de4-a7d5-374d9af5d320
DOI
10.1101/2022.09.09.507376
Open publication

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