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Article

YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis.

Nature communications - 22 Sept 2023

Wu Zhengming, Su Junhui, Li Fu-Long, Chen Tao, Mayner Jaimie, Engler Adam, Ma Shenghong, Li Qingquan, Guan Kun-Liang

Abstract excerpt

Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs have inactivating mutations in TP53 and RB1. We find that loss of YAP expression is key for SCLC cells to acquire rapid ameboid migration and high metastatic potential. YAP functions through its target genes CCN1/CCN2 to inhibit SCLC ameboid migration. RB1 mutation contributes to YAP transcriptional silencing via E2F7,...

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Identifiers

PMID: 37739954
DOI: 10.1038/s41467-023-41585-z
PMCID: PMC10516997

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