Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies.

doi:10.1158/1078-0432.CCR-23-2360

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Article

Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2024

Ng Jin, Cai Ling, Girard Luc, Prall Owen W J, Rajan Neeha, Khoo Christine, Batrouney Ahida, Byrne David J, Boyd Danielle K, Kersbergen Ariena J, Christie Michael, Minna John D, Burr Marian L, Sutherland Kate D

Abstract excerpt

PURPOSE: The classification of small cell lung cancer (SCLC) into distinct molecular subtypes defined by ASCL1, NEUROD1, POU2F3, or YAP1 (SCLC-A, -N, -P, or -Y) expression, paves the way for a personalized treatment approach. However, the existence of a distinct YAP1-expressing SCLC subtype remains controversial. EXPERIMENTAL DESIGN: To better understand YAP1-expressing SCLC, the mutational landscape of human...

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PMID: 38180245
DOI: 10.1158/1078-0432.CCR-23-2360
PMCID: PMC11061608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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