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Article

Loss of the SWI/SNF ATPase subunits BRM and BRG1 drives lung cancer development

17 Nov 2016

Abstract excerpt

accelerated lung tumor development, shortened tumor latency, and caused a loss of differentiation. Tumors with Brg1 and/or Brm loss recapitulated the evolution of human lung cancer as observed by the development of local tumor invasion as well as distal tumor metastasis, thereby making this model useful in lung cancer studies. Brg1 loss contributed to metastasis in part by driving E-cadherin loss and Vimentin...

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PMID: 28105457
DOI: 10.18632/oncoscience.323

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