Article

Brief report: Reclassifying SCLC-Y as SMARCA4 deficient malignancies - resolving the controversy

2022-10-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> The classification of small cell lung cancer (SCLC) into distinct molecular subtypes defined by ASCL1, NEUROD1, POU2F3 or YAP1 expression, paves the way for the development of targeted therapeutics. However, the existence of a distinct YAP1-expressing SCLC subtype remains controversial. Here we have undertaken a detailed molecular and histological characterisation of YAP1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16e0b6d7-4755-5d9f-b7a9-4f12f1b1a9a4
DOI: 10.1101/2022.10.09.511505

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brief report: Reclassifying SCLC-Y as SMARCA4 deficient malignancies - resolving the controversyDOI 10.1101/2022.10.09.511505Read

Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies.Semantic proximity Read

SMARCA4-deficient thoracic malignancies with small cell lung cancer-like features: A clinicopathological and molecular study of a heterogeneous group.Semantic proximity Read

Molecular Subtypes and Targeted Therapeutic Strategies in Small Cell Lung Cancer: Advances, Challenges, and Future PerspectivesSemantic proximity Read

Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformationSemantic proximity Read

Origins, genetic landscape, and emerging therapies of small cell lung cancer.Semantic proximity Read

Small cell lung cancer: emerging subtypes, signaling pathways, and therapeutic vulnerabilitiesSemantic proximity Read

Molecular classification of small cell lung cancer subtypes: Characteristics, prognostic factors, and clinical translation.Semantic proximity Read

Perspectives and Issues in the Assessment of SMARCA4 Deficiency in the Management of Lung Cancer Patients.Semantic proximity Read

SCLC-State of the Art and What Does the Future Have in Store?Semantic proximity Read

SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signaturesSemantic proximity Read

Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenograftsSemantic proximity Read

Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter studySemantic proximity Read