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Article

SMARCA4-deficient thoracic malignancies with small cell lung cancer-like features: A clinicopathological and molecular study of a heterogeneous group.

Annals of diagnostic pathology - 1 Aug 2026

Ding Jie-Rong, Li Xue-Guang, Wang Xuan, Cheng Kai, Xia Qiu-Yuan, Xu Man-Yu, Zhang Ru-Song, Fang Ru, Wang Xiao-Xia, Wu Nan, Rao Qiu

Abstract excerpt

OBJECTIVES: To characterize SMARCA4-deficient thoracic malignancies with small cell lung cancer (SCLC)-like features as a heterogeneous disease spectrum. MATERIALS AND METHODS: We retrospectively reviewed our pathological archives and identified three cases that exhibited both immunohistochemical loss of SMARCA4 and "SCLC-like features," defined as the presence of characteristic SCLC histomorphology (per WHO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41855992
DOI: 10.1016/j.anndiagpath.2026.152638

Genes

SMARCA4
RB1
ASCL1
TP53
NEUROD1
POU2F3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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