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A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies <i>cis-</i> and <i>trans-</i> regulatory elements of <i>Oct4</i> in murine ESCs

2019-11-22

Abstract excerpt

Regulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the non-coding genome and control gene expression programs either in –cis or in – trans . Putative REs have been identified largely based on their regulatory features (co-occupancy of ESC-specific transcription factors, enhancer histone marks and DNase hypersensitivity) in mouse embryonic stem cells (mESCs). However...

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Literature Corpus work
1c06108e-2640-5264-a64b-40fd2056e7b4
DOI
10.1101/851683
Open publication

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A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies <i>cis-</i> and <i>trans-</i> regulatory elements of <i>Oct4</i> in murine ESCsDOI 10.1101/851683
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