Article

Enhancers display constrained sequence flexibility and context-specific modulation of motif function

2022-09-01

Abstract excerpt

The information about when and where each gene is to be expressed is mainly encoded in the DNA sequence of enhancers, sequence elements that comprise binding sites (motifs) for different transcription factors (TFs). Most of the research on enhancer sequences has been focused on TF motif presence, while the enhancer syntax, i.e. the flexibility of important motif positions and how the sequence context modulates the...

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Literature Corpus work: eeb60258-d2b7-5f75-a251-7feec3b4cebd
DOI: 10.1101/2022.08.31.506061

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