Article

Type 2 Diabetes Partitioned Polygenic Scores Are Differentially Associated with Aging Hallmarks

2026-07-09

Abstract excerpt

Type 2 diabetes (T2D) arises from distinct diabetogenic mechanisms, but whether these mechanisms differ in their associations with hallmarks of aging remains unclear. We analyzed 449,505 UK Biobank and 374,973 All of Us participants using an overall T2D polygenic score (oPS) and eight partitioned polygenic scores (pPSs) representing distinct T2D-related mechanisms. Across organ systems, 81 age-related diseases we...

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Literature Corpus work: 6030d222-09f5-5b08-b10c-78b8a895fe20
DOI: 10.64898/2026.07.06.26357294

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