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Article

Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes.

Diabetes - 1 Aug 2024

Billings Liana K, Jablonski Kathleen A, Pan Qing, Florez Jose C, Franks Paul W, Goldberg Ronald B, Hivert Marie-France, Kahn Steven E, Knowler William C, Lee Christine G, Merino Jordi, Huerta-Chagoya Alicia, Mercader Josep M, Raghavan Sridharan, Shi Zhuqing, Srinivasan Shylaja, Xu Jianfeng, Udler Miriam S

Abstract excerpt

Partitioned polygenic scores (pPS) have been developed to capture pathophysiologic processes underlying type 2 diabetes (T2D). We investigated the association of T2D pPS with diabetes-related traits and T2D incidence in the Diabetes Prevention Program. We generated five T2D pPS (β-cell, proinsulin, liver/lipid, obesity, lipodystrophy) in 2,647 participants randomized to intensive lifestyle, metformin, or placebo...

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Share to Diabetes Mellitus, Type 2
Share to Diabetes, Cardiovascular Risks, and Lipoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Associations and Epidemiology

Share to Genetic Predisposition to Disease

Share to Incidence

Share to Insulin-Secreting Cells

Share to Multifactorial Inheritance

Share to Prediabetic State

Source

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Identifiers

PMID: 38758294
DOI: 10.2337/db23-0761
PMCID: PMC11262049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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