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Article

Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation.

Nature reviews. Endocrinology - 1 Sept 2025

Ortega Hector I, Udler Miriam S, Gloyn Anna L, Sharp Seth A

Abstract excerpt

Diabetes mellitus encompasses several disorders, each with differing clinical presentation, prognoses and pathophysiology. Distinct polygenic architectures underlie type 1 diabetes mellitus and type 2 diabetes mellitus, and govern numerous pathophysiological pathways that converge on dysglycaemia. Over the previous decade, polygenic risk scores (PRS) derived from large genome-wide association studies have become...

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Identifiers

PMID: 40467969
DOI: 10.1038/s41574-025-01132-w
PMCID: PMC12614124

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