Article

Multi-omic signatures of genetic mechanisms inform on type 2 diabetes biology and patient heterogeneity

2026-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Type 2 diabetes (T2D) is a heterogeneous disease shaped by genetic pathways related to insulin resistance and β-cell dysfunction, but how this heterogeneity is reflected molecularly remains unclear. We integrated partitioned polygenic scores (pPS) with proteomic and metabolomic profiling to define molecular signatures of T2D and their clinical relevance. We analyzed UK Biobank participants with...

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Literature Corpus work: c0f3e008-bbfd-5edd-934d-82f6e6842734
DOI: 10.64898/2026.04.17.26351136

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