Article

Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score

2024-08-22

Abstract excerpt

Combining information from multiple GWASs for a disease and its risk factors has proven a powerful approach for development of polygenic risk scores (PRSs). This may be particularly useful for type 2 diabetes (T2D), a highly polygenic and heterogeneous disease where the additional predictive value of a PRS is unclear. Here, we use a meta-scoring approach to develop a metaPRS for T2D that incorporated genome-wide a...

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Literature Corpus work: 75314e35-cb69-5cfd-9e29-5a9c532d8df0
DOI: 10.1101/2024.08.22.24312440

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