Article

Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities

2024-03-19

Abstract excerpt

<h4>Introduction</h4> Type 2 diabetes (T2D) is a heterogeneous disorder for which disease-causing pathways are incompletely understood. Here, we mapped genetic risk for T2D and its comorbidities to proteins, mechanistic pathways and clinical outcomes using proteogenomic data from a population-scale biobank and two randomized controlled trials. <h4>Methods</h4> We tested polygenic scores (PGS) for T2D and its cardi...

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Literature Corpus work: 2eb363a0-7108-5788-b6ad-c86b3ff7d755
DOI: 10.1101/2024.03.15.24304200

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