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Type 2 Diabetes Genetic Risk and Type 1 Diabetes Heterogeneity and Progression.

Diabetes - 20 Jan 2026

Triolo Taylor M, Sosenko Jay M, Cuthbertson David, Oram Richard A, Parikh Hemang M, Steck Andrea K, Sims Emily K, Jacobsen Laura M, Nathan Brandon, Templeman Erin L, Onengut-Gumuscu Suna, Evans-Molina Carmella, Rich Stephen S, Atkinson Mark A, Redondo Maria J

Abstract excerpt

Insulin secretion varies widely in preclinical type 1 diabetes. To understand the pathogenesis of this metabolic heterogeneity, we asked whether genetic predisposition to type 2 diabetes, quantified by a type 2 diabetes genetic risk score (T2D-GRS), modulates β-cell function and disease progression in individuals at risk of type 1 diabetes. We analyzed 4,324 islet autoantibody–positive TrialNet Pathway to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41369591
DOI: 10.2337/db25-0711
PMCID: PMC12823339

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