Article

Multi-molecular scores map process-specific polygenic diabetes risk to atherosclerosis, cardiometabolic diseases, and vascular complications

2026-01-16

Abstract excerpt

Type 2 diabetes (T2D) is etiologically heterogeneous, and process-specific polygenic scores (pPSs) only partly resolve this complexity. Here we integrate fourteen published T2D pPSs with plasma biochemistry, proteomics and NMR metabolomics in 29,425 SCAPIS participants to derive process-specific, polygenic-informed multi-molecular scores (pMMSs) that map genetic risk onto multi-omic molecular signatures. We then t...

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Literature Corpus work: 3356589c-4b91-51d9-971f-a80cc52c2815
DOI: 10.64898/2026.01.15.26344187

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