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High-throughput Genetic Clustering of Type 2 Diabetes Loci Reveals Heterogeneous Mechanistic Pathways of Metabolic Disease

2022-07-12

Abstract excerpt

<h4>Aims/hypothesis</h4> Type 2 diabetes (T2D) is highly polygenic and influenced by multiple biological pathways. Rapid expansion in the number of T2D loci can be leveraged to identify such pathways, thus facilitating improved disease management. <h4>Methods</h4> We developed a high-throughput pipeline to enable clustering of T2D loci based on variant-trait associations. Our pipeline extracted summary statistics...

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Literature Corpus work
abe9f2ee-f467-52ae-b4bc-bce2494e9e35
DOI
10.1101/2022.07.11.22277436
Open publication

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High-throughput Genetic Clustering of Type 2 Diabetes Loci Reveals Heterogeneous Mechanistic Pathways of Metabolic DiseaseDOI 10.1101/2022.07.11.22277436
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