Article
Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts.
Diabetes care - 1 Mar 2022
DiCorpo Daniel, LeClair Jessica, Cole Joanne B, Sarnowski Chloé, Ahmadizar Fariba, Bielak Lawrence F, Blokstra Anneke, Bottinger Erwin P, Chaker Layal, Chen Yii-Der I, Chen Ye, de Vries Paul S, Faquih Tariq, Ghanbari Mohsen, Gudmundsdottir Valborg, Guo Xiuqing, Hasbani Natalie R, Ibi Dorina, Ikram M Arfan, Kavousi Maryam, Leonard Hampton L, Leong Aaron, Mercader Josep M, Morrison Alanna C, Nadkarni Girish N, Nalls Mike A, Noordam Raymond, Preuss Michael, Smith Jennifer A, Trompet Stella, Vissink Petra, Yao Jie, Zhao Wei, Boerwinkle Eric, Goodarzi Mark O, Gudnason Vilmundur, Jukema J Wouter, Kardia Sharon L R, Loos Ruth J F, Liu Ching-Ti, Manning Alisa K, Mook-Kanamori Dennis, Pankow James S, Picavet H Susan J, Sattar Naveed, Simonsick Eleanor M, Verschuren W M Monique, Willems van Dijk Ko, Florez Jose C, Rotter Jerome I, Meigs James B, Dupuis Josée, Udler Miriam S
Abstract excerpt
OBJECTIVE: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations with 47 diabetes-related traits and identified five clusters, termed β-cell, proinsulin, obesity, lipodystrophy, and liver/lipid. The relationship between these clusters and...
Read the complete abstract on PubMed