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Article

Effect of fibroblast heterogeneity on prognosis and drug resistance in high-grade serous ovarian cancer

4 Nov 2024

Abstract excerpt

Tumor heterogeneity is associated with poor prognosis and drug resistance, leading to therapeutic failure. Here, we used tumor evolution analysis to determine the intra- and intertumoral heterogeneity of high-grade serous ovarian cancer (HGSOC) and analyze the correlation between tumor heterogeneity and prognosis, as well as chemotherapy response, through single-cell and spatial transcriptomic analysis. We...

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PMID: 39496775
DOI: 10.1038/s41598-024-77630-0

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