Article

M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans

2025-06-30

Abstract excerpt

Deposition of CENP-A, the histone H3 variant considered an epigenetic landmark of centromeres, reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The localization determinants of this machinery remain poorly characterized. Here we report that artificial M18BP1 dimerization bypasses MIS18α/β, allowing the identification of at least four determinants of M18BP1 centrome...

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Literature Corpus work: 5ffbffa5-6dac-5d9b-a04c-fa1d50ffe6bd
DOI: 10.1101/2025.06.27.661933

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