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Article

Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.

The EMBO journal - 1 Apr 2020

Medina-Pritchard Bethan, Lazou Vasiliki, Zou Juan, Byron Olwyn, Abad Maria A, Rappsilber Juri, Heun Patrick, Jeyaprakash A Arockia

Abstract excerpt

Centromeres are microtubule attachment sites on chromosomes defined by the enrichment of histone variant CENP-A-containing nucleosomes. To preserve centromere identity, CENP-A must be escorted to centromeres by a CENP-A-specific chaperone for deposition. Despite this essential requirement, many eukaryotes differ in the composition of players involved in centromere maintenance, highlighting the plasticity of this...

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Identifiers

PMID: 32134144
DOI: 10.15252/embj.2019103234
PMCID: PMC7110144

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